The research group of Juntendo University's assistant Shigeaki Imoto and others has collaborated with Asahi Group Holdings, Inc. Core Technology Research Institute and Iwate Prefectural Iwai Hospital to determine the occupancy rate of bifidus in the intestinal tract in the early infancy of Japanese people immediately before delivery. It was clarified that it decreased by administration of antibacterial drug to the mother.
As many as 100 to 1000 trillion bacteria are established in the human intestine, and it is called "intestinal flora (intestinal flora)".In infants, changes in the proportion (occupancy rate) of intestinal bacterial species, especially bifidobacteria, and colonization in the intestinal tract during the first 6 months of life are thought to affect the onset of diseases such as allergies.Delivery patterns and nutrition may affect this colonization, but the factors are unknown.
A study found how the administration of antibiotics into maternal blood vessels, which may be used to prevent infection during labor, affects the intestinal flora of early infants in the feces of 33 healthy Japanese infants. Was collected and verified.
As a result, the occupancy rate of bifidobacteria was significantly reduced by the administration of the antibacterial drug into the maternal blood, and a clear difference was observed in the diversity of intestinal bacteria depending on the presence or absence of the antibacterial drug administration.On the other hand, there was no significant difference in the occupancy rate of bifidobacteria and the diversity of intestinal bacteria due to the difference in delivery mode (caesarean section natural delivery).
In the future, it will be important to elucidate the clinical significance of the difference in colonization of bifidobacteria and the difference in the diversity of the intestinal flora.In addition, since administration of antibiotics immediately before delivery is essential for safe delivery, some intervention (such as the use of probiotics) to promote the colonization of bifidobacteria in babies born to mothers who received antibiotics. ) Is also suggested.
