Visiting Professor Ikuhisa Fujita of the Graduate School of Pharmaceutical Sciences, Osaka University, Professor Akari Morita of the Graduate School of Medicine, Nagoya City University, and former Professor Ken Ishii of the Institute for Biomedical Innovation, Health and Nutrition (currently Professor of the Institute of Medical Science, the University of Tokyo) The research group discovered for the first time in the world that human primary immune cells contain organelles called primary cilia.
According to major cosmetics company Mandom Co., Ltd., which is conducting joint research with Osaka University, primary cilia are organelles that protrude from the cell surface of mammals and play a role similar to antennas that transmit signals inside and outside the cells.However, it has not been confirmed whether it is present in immune cells taken directly from human blood.
The research group also found that the number of cells with primary cilia increased when dendritic cells, which act as command centers of immunity, were stimulated with allergenic factors.In addition, the number of primary cilia-bearing epidermal keratinocytes in inflamed skin due to atopic dermatitis and psoriasis also increased, suggesting that primary cilia are involved in the control of skin inflammation. discovered.
Mandom believes that by analyzing the immune response function of primary cilia, we can expect the mechanism of inflammatory diseases, the development of new therapeutic agents, and the application in the industrial field.
Paper information:[Frontiers in molecular Biosciences] Dendritic cell proliferation by primary cilium in atopic dermatitis
[Experimental Dermatology] Increase in primary cilia in the epidermis of patients with atopic dermatitis and psoriasis
