Kaoru Park, a sixth-year student at Kagawa University School of Medicine, discovered a new structure in which a molecule called DENND6B exists as a linear aggregate in the cell.This structure is an unknown one that has never been reported in the world, and this result was published in the online version of Histochemistry and Cell Biology (published by Springer Nature), the journal of the German Society for Organizing, as the first paper by Mr. Park. It was released on November 1rd.It is extremely rare for an undergraduate student to publish a dissertation as the lead author in an international academic journal.
From the second grade, Park takes a break from lectures and practical training to observe the behavior of molecules fused with GFP fluorescent protein in living cultured cells in the laboratory of the Department of Tissue Cell Biology (live cell imaging). ) I have been doing research voluntarily.This time, when the intracellular localization of the GFP-fused DENND2B protein was observed by live cell imaging technology, we found a structure in which DENND1B exists in the form of a linear aggregate on the intracellular basal side. The DENND1B protein is known as an activator of the Rab1 protein, but since it was found in the base of adherent cultured cells, especially at the base of lamelipodia (pseudopodia), it is involved in Rab35 activation. It was presumed that the structure functions in relation to cell adhesion and migration.
If research on the function and molecular mechanism of this new intracellular structure, which has not been reported at all, can be further developed in the future, it is expected to contribute to the elucidation of the moistening mechanism of cancer cells.
Paper information:[Histochemistry and Cell Biology] A novel DENND1B-localized structure found at the basal side of adherent cells