A research group at Tokyo Medical and Dental University, in collaboration with California University, Tsukuba University, Chiba University, and Soak Institute, found that anti-inflammatory unsaturated fatty acids produced by macrophages are important for converging the inflammatory response. Revealed.It is said that it will lead to the development of new treatment and prevention methods for lifestyle-related diseases.

 The development of treatment / prevention methods for lifestyle-related diseases such as obesity and diabetes has become a major issue.Lifestyle-related diseases are said to develop on the basis of "chronic inflammation" in which inflammation does not converge and is prolonged, but the mechanism of chronic inflammation has not been clarified.

 Macrophages are immune cells with various functions and play an important role in the pathogenesis of lifestyle-related diseases.When these macrophages are indirectly stimulated to cause inflammation, they are activated to promote an inflammatory response.It was found that this stimulation reduces the function of the nuclear receptor (LXR), stops the synthesis of unsaturated fatty acids that suppress inflammation, and macrophages show the function of promoting inflammation.However, in the late stage of the inflammatory response (24 hours after stimulation), the transcription factor (Srebp1) acts to increase the synthesis of unsaturated fatty acids, which was once reduced.It was found that the action of this unsaturated fatty acid suppresses the inflammatory response and activity of macrophages, and the inflammation tends to converge. It was also found that the deficiency of Srebp1 causes the inflammatory response to not converge well or to prolong, but it converges properly when given unsaturated fatty acids.

 Here, we find that macrophage lipid metabolism and its function in inflammation are closely regulated, and that unsaturated fatty acids produced by macrophages are important for the proper convergence of inflammation.In the future, it is expected to develop new treatment / prevention methods for lifestyle-related diseases targeting the lipid metabolism (synthesis and decomposition) of macrophages.

Tokyo Medical and Dental University

Fostering excellent global medical personnel with rich humanity based on the history and achievements of close cooperation between medicine and dentistry

As Japan's only comprehensive medical graduate university, in the fields of medicine and dentistry, human resources who can play an active role on the world stage, a wide range of education and rich humanity, high ethical standards, creativity and pioneering ability to think and solve by oneself, internationality Foster human resources with leadership skills.Excellent faculty, excellent facilities, and a world-class curriculum […]

University of Tsukuba

Continue to challenge interdisciplinary fusion and internationalization, and develop human resources with intelligence and humanity

University of Tsukuba is the core of Tsukuba Science City, an international city with a high academic and cultural scent.The current education system is 9 groups, 23 classes, and it is possible to take specialized introductory courses from all fields, aiming to have creative intelligence and rich humanity.Solving global issues with soul genius […]

Chiba University

Fostering human resources who will open up the next generation.To a future-oriented university that shines in the world

Chiba University has 10 faculties, 7 graduate schools / faculties, and a large number of affiliated facilities, and has specialized knowledge and skills, high problem-solving ability, high intelligence, ethical standards, and rich humanity, and has an interdisciplinary perspective. We aim to develop human resources who can play an active role internationally.Actively promote the enhancement of liberal arts education and the internationalization of educational activities, which are the basis of this […]

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