A research group led by Assistant Professor Asami Yagi (full-time) and Lecturer Yutaka Ueda at the Graduate School of Osaka University created a catch-up for those who missed the opportunity to get the HPV vaccine to prevent cervical cancer during the period when the recommendation was withheld. Several scenarios of up-vaccination rates were set, and simulations were conducted to predict how much the increase in cervical cancer risk caused by reduced vaccination rates due to withholding of active recommendations could be reduced.
The main cause of cervical cancer is high-risk HPV infection, including human papillomavirus (HPV) types 16 and 18.Cervical cancer is on the decline in other developed countries due to the introduction of the HPV vaccine, but it is increasing in Japan in recent years. From June 2013 to November 6, active recommendations by the Ministry of Health, Labor and Welfare were withheld due to concerns about various symptoms reportedly occurring after vaccination.
The research group estimated the relative risk for women born in 1993 and beyond, assuming that the lifetime risk of cervical cancer incidence and mortality for women born in 1994, before the start of public-funded HPV vaccination, was XNUMX.We examined the necessary regular and catch-up vaccination rates to reduce the risk increase caused by the decrease in vaccination rates due to the withdrawal of active recommendations.
As a result of comparing the case where the required vaccination rate is reached in 3 years (FY 2022-2024) and the case where it is achieved in 1 year (FY 2022), the highest vaccination rate is achieved in 1 when 90% is achieved in 1997 year. It was found that even birth risk can be reduced.
According to this study, even if the vaccination rate (90%) was achieved over three years before the active recommendation was withheld, the risk increased due to the decrease in the vaccination rate due to the withholding of the active recommendation in 3. It turns out that the risk of birth cannot be reduced.It is important to increase the vaccination rate at an early stage by implementing measures to encourage vaccination.
Paper information:[Vaccines] Can Catch-Up Vaccinations Fill the Void Left by Suspension of the Governmental Recommendation of HPV Vaccine in Japan?
