Even if the type of cancer is the same, the nature of the cancer varies depending on the individual patient and the stage.Therefore, in order to expect a sufficient effect, it is necessary to individually select an anticancer drug suitable for each patient, but in the current cancer treatment, an anticancer drug similar to the same type of cancer is available. Often used.

　In this study, when a hole was made in the shell of a fertilized chicken egg and finely crushed human ovarian cancer was placed on the "allantois membrane" surrounding the embryo, the same characteristics were obtained in a very short period of time (3-4 days later). Cancer with ovarian cancer was reproduced in chicken eggs (it takes several weeks in mice).With this egg model, it will be possible to reproduce the cancer of an actual patient and find the best drug for that cancer at low cost in about a week.

　Furthermore, when an anticancer drug was embedded in the newly developed porous (with innumerable pores) nanoparticles "B-PMO" and administered to this chicken egg model, the cancer disappeared in 2 to 3 days. The embryonic organs were healthy. Since B-PMO gathered and accumulated only in the cancer, it did not affect the surrounding organs and the side effects of the anticancer drug could be minimized.

　From this result, it is expected that the egg model will be useful for the realization of individual medical care.In addition, nanoparticles B-PMO can be useful for anti-cancer drug treatment with few side effects, and by verifying the mechanism of its high cancer storage capacity, it can be useful for the development of particles with even higher cancer storage capacity. Be expected.

Paper information:[Scientific Reports] Chick chorioallantoic membrane assay as an in vivo model to study the effect of nanoparticle-based anticancer drugs in ovarian cancer