A research group led by Associate Professor Eijiro Miyako of the Frontier Research Area for Materials Chemistry, Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology, succeeded in isolating multiple bacteria with potent anti-tumor effects from tumor tissue in mice.
It has been known for a long time that bacteria exist in tumor tissues, and recent studies have revealed that the intratumoral flora is a factor that assists or inhibits anticancer drugs.However, until now, there has been no research on extracting bacteria in tumors and utilizing them as therapeutic agents for cancer.
In this study, we succeeded in isolating and identifying mainly three types of bacteria from colon cancer-derived tumor tissues in vivo in mice. and UN-gyo were named AUN.
When these bacteria were administered to tumor-bearing model mice subcutaneously implanted with colorectal cancer, they found that they could highly selectively accumulate, grow, and proliferate in the tumor environment, and showed high antitumor effects.In particular, AUN effectively activates cytotoxic immune cells through the concerted action of A-gyo and UN-gyo, and is effective against various cancer types such as colon cancer, sarcoma, metastatic lung cancer, and drug-resistant breast adenocarcinoma. showed potent antitumor activity againstIt is said that cancer cells are killed by “Aun no Breathing”.We also found that AUN exhibited strong fluorescence in the target tumors when irradiated with near-infrared light.
In conventional cancer bacterial therapy, the concept of transporting anticancer drugs (drug delivery system) was not used, and Salmonella and Listeria bacteria attenuated by genetic recombination were often used, and there was a risk of becoming more virulent again in the body. Accompany.On the other hand, AUN is, so to speak, a bacterium that exists in tumors under the lighthouse, and it was confirmed in biocompatibility tests using mice that it has extremely little effect on the living body.
The results of this research are expected not only to provide a basis for the development of cancer diagnostic and therapeutic methods using AUN, but also to create new concepts in research areas such as bacteriology and tumor microbiology.
Paper information:[Advanced Science] Discovery of Intratumoral Oncolytic Bacteria Toward Targeted Anticancer Theranostics
