A research group led by Associate Professor Keitaro Omori of the Graduate School of Tokyo University of Agriculture and Technology conducted joint research with Anicom Advanced Medical Research Institute Co., Ltd., and conducted fecal transplantation therapy in which feces from healthy dogs were transplanted into dogs with atopic dermatitis. It was found that it improved the intestinal flora of dogs with inflammation and reduced clinical symptoms such as dermatitis and itching.
Fecal transplantation therapy (FMT) is a treatment method called "intestinal microbiota transplantation" that improves the constitutional abnormalities of the intestinal microbiota, and its effects on various diseases have been verified.The research group has so far reported the efficacy of FMT for canine digestive disorders, etc., but the efficacy of FMT for dogs with atopic dermatitis has not been verified.
The research group first compared and analyzed the intestinal flora of dogs with atopic dermatitis and healthy dogs.As a result, in dogs with atopic dermatitis, the diversity of the intestinal microflora was reduced, and the so-called bad bacteria tended to increase.Furthermore, the number and variety of bacteria decreased, and the composition of the intestinal microflora differed greatly from that of healthy dogs.
Next, FMT was performed once by orally administering a fecal solution prepared from fresh feces of healthy dogs to dogs with atopic dermatitis.As a result, dermatitis and itching associated with atopic dermatitis were significantly improved.In addition, the intestinal microbiota of dogs with atopic dermatitis resembled those of healthy dogs, and the number and variety of bacteria improved as the number of bad bacteria decreased.This suggested that oral FMT normalized the intestinal flora of dogs with atopic dermatitis and alleviated clinical symptoms.Also, no serious adverse events were observed after oral FMT.
Oral FMT is a simple treatment that does not require anesthesia or sedation and does not require special equipment such as an endoscope.In the future, we aim to develop an efficient and simple oral FMT method by analyzing effective bacteria that improve clinical symptoms in dogs with atopic dermatitis.
Paper information:[Scientific Reports] Pilot evaluation of a single oral fecal microbiota transplantation for canineatopic dermatitis
