Osteoarthritis is the most common arthritis in the world, and there is a strong need to understand its pathology.Among the types of osteoarthritis, developmental hip dysplasia, in which the hip joint is underdeveloped and prone to cartilage wear, has been pointed out as a risk factor for hip osteoarthritis, which causes hip pain.Understanding the pathology of developmental hip dysplasia will lead to a better understanding of hip osteoarthritis, but the pathology and the factors that lead to hip osteoarthritis are not fully understood, especially genetic factors.

　The research group obtained detailed family history information from 293 patients with developmental hip dysplasia.The presence or absence of a relative with developmental hip dysplasia and the relative rank of the relative were tabulated for each patient and used as an index of the strength of the genetic component.

　The results showed that patients with more relatives with developmental hip dysplasia had a younger age at onset of hip pain.Additionally, patients who have a close relative with developmental hip dysplasia have a higher risk of undergoing joint replacement surgery than patients without such a relative, and follow-up from the onset of hip pain to joint replacement surgery is important. It was also confirmed that the period was short.

　The present results indicate that genetic risk for developmental hip dysplasia is involved in the onset and severity of hip osteoarthritis.This guarantees the value of genetic research on developmental hip dysplasia and hip osteoarthritis at the genomic level, and it is hoped that future genomic research will elucidate the pathology of both diseases.

Paper information:[The Journal of Arthroplasty] Family history of developmental dysplasia of the hip is a risk factor for the progression of hip osteoarthritis