Researcher Wu Xuefeng of Keio University School of Medicine Center for Oriental Medicine, Tetsudai Specially Appointed Lecturer Yoshino, Emeritus Professor Masaru Mimura, research groups from Tsumura, a traditional Chinese medicine company, and DeNA Life Sciences, a health care business, have conducted comprehensive genome analysis to Found a related gene.
According to Keio University, the research subjects were 20 women between the ages of 60 and 1,111, and 599 of them were aware of their coldness. The group who were aware of their coldness tended to have lower body weight and less exercise habits than the group who were not aware of it. Subjective symptoms were significantly higher in the group that was aware of being cold, and symptoms increased as the degree of coldness became more severe.
The research group conducted a comprehensive genome analysis and identified 11 genomic regions, of which the rs2 single nucleotide polymorphism near the KCNK1869201 gene and the rs2 gene polymorphism on the TRPM4818919 gene are associated with the risk of sensitivity to cold. It has been suggested. These factors appear to change the expression levels of proteins associated with sensitivity to cold, increasing risk.
Cold is a symptom in which the whole body or parts of the body feel cold, even though there is no organic abnormality. Sensitivity to cold is when a person's sensitivity to cold interferes with their daily life, leading to a decline in quality of life due to insomnia, fatigue, pain, etc., and is thought to be a trigger for other illnesses.
Vasomotor neuropathy, imbalance of female hormones, and decreased body temperature regulation have been suggested as mechanisms for sensitivity to cold, but there has been no comprehensive genome analysis study related to sensitivity to cold.
Paper information:[Scientific Reports] Exploratory study of cold hypersensitivity in Japanese women: genetic associations and somatic symptom burden
