A collaborative research group led by Soichi Kojima, a special unit leader at RIKEN, and Professor Hiroyuki Kagechika of Tokyo Medical and Dental University, has clarified the mechanism by which peretinoin, which is expected to prevent the recurrence of liver cancer, works.

 The number of liver cancer deaths in Japan peaked in the early 2000s and is declining.On the other hand, it is the second leading cause of death among all cancer types in the world.Liver cancer has a high probability of recurrence after surgery to remove the tumor and is known to have an extremely poor prognosis.Peretinoin has the effect of reducing the risk of recurrence to 2% or less by selectively killing liver cancer cells, and is being clinically tested as the world's first preventive measure against liver cancer recurrence.Peretinoin has been shown to have no effect on normal cells and selectively kill liver cancer cells.Kojima Unit Leaders and colleagues have discovered in previous studies that peretinoin has the ability to collect a protein called TG20 around the cell nucleus.This suppressed the expression of genes essential for the survival of cancer cells.However, the details of its function were not well understood.

 In this study, we investigated which parts play an important role in gathering inside the nucleus by suppressing the functions of each of the four components that make up TG2 by recombining genes.As a result, we found that one component was needed to get inside the nucleus.This is because it binds to substances that carry proteins into the nucleus.And peretinoin played a role in promoting these bonds.

 It has become clear that the migration of TG2 into the nucleus by peretinoin is the cause of the death of liver cancer cells.In the future, if we can discover substances that cause TG2 migration more efficiently than peretinoin, it may lead to the development of more effective recurrence preventive drugs.

Tokyo Medical and Dental University

Fostering excellent global medical personnel with rich humanity based on the history and achievements of close cooperation between medicine and dentistry

As Japan's only comprehensive medical graduate university, in the fields of medicine and dentistry, human resources who can play an active role on the world stage, a wide range of education and rich humanity, high ethical standards, creativity and pioneering ability to think and solve by oneself, internationality Foster human resources with leadership skills.Excellent faculty, excellent facilities, and a world-class curriculum […]

University Journal Online Editorial Department

This is the online editorial department of the university journal.
Articles are written by editorial staff who have a high level of knowledge and interest in universities and education.
For inquiries and opinions regarding the content of articles, etc. hereThank you.