"Acute renal disorder", in which the function of the kidney suddenly deteriorates, becomes more advanced when it is affected by lifestyle-related diseases such as hypertension and diabetes, and it is often diagnosed as chronic kidney disease in the end.In acute kidney injury, it has been pointed out that a large amount of "oxidative stress", which is a state in which molecules that damage cells such as reactive oxygen species are accumulated, occurs and gradually damages the kidney. It is considered difficult to extinguish.

　The research group aimed to reduce oxidative stress at the stage of acute renal injury and prevent the progression to chronic kidney disease, and created genetically modified mice with high ability to eliminate oxidative stress and conducted experiments.

　As a result, it was found that the genetically modified mouse had a mild condition of chronic kidney disease.Subsequently, as a result of giving mice with acute renal injury a drug that increases resistance to oxidative stress, the drug was given between the 1st to 5th days after the onset, and the progression to chronic kidney disease was suppressed. Was done.On the other hand, there was no effect on the mice administered after the 7th day.

　From the above experiments, it was clarified that oxidative stress causes the progression of kidney disease.It was also found that the progression to chronic kidney disease is suppressed by increasing resistance to oxidative stress at an early stage after acute kidney injury.

　Chronic kidney disease is a national disease that affects 8 in 1 adults in Japan, but no silver bullet has yet been developed.In this study, clinical trials using the same drugs as those administered to mice have already been conducted, and it is expected that they will contribute to the development of new drugs that prevent the onset and progression of chronic kidney disease in the future.