A research group led by Assistant Professor Hironichi Ryo of the International Research Institute for Disaster Science, Tohoku University revealed that osteopontin (OPN), a severity marker protein, is induced by dengue virus infection in monocyte-derived cell lines in dengue virus infection. bottom.Furthermore, it was suggested that not only the cellular slime mold component brefelamide suppresses the production of OPN by this virus, but also the possibility of preventing the release of dengue virus itself from cells.
Dengue virus infection is a mosquito-borne infection that infects less than 4 million people worldwide annually and is estimated to affect nearly 1 million people.Even in Japan, where most of the cases were imported infections, the onset has been seen in Japan in recent years.In addition, about 2 people have died worldwide due to severe cases such as dengue hemorrhagic fever.The research group had previously announced that OPN was extremely high in plasma of dengue-infected patients, which correlates with severity and bleeding tendency.
This time, the research group developed the presentation and found that infecting THP-1 cells derived from human monocytes established at Tohoku University with dengue virus significantly increased the expression of OPN gene / protein levels.In addition, it was clarified that the addition of brefelamide, a cellular slime mold component known to suppress the production of OPN, suppresses the production of OPN and suppresses inflammation in dengue infection.In addition, it was clarified that brefelamide has the effect of suppressing the release of the virus, which was the subject of future research.
This finding has attracted attention as a suggestion for the existence of new therapies targeting OPNs involved in the aggravation of dengue virus.
Paper information:[Frontiers in Microbiology] Induction of Osteopontin by Dengue Virus-3 infection in THP-1 cells-Inhibition of the synthesis by Brefelamide and its derivative-
