Top > Research results > Medical > Succeeded in chemical synthesis of new artificial insulin, to reduce the burden on diabetic patients Tokai University, etc.

2017/4/16

Succeeded in chemical synthesis of new artificial insulin, to reduce the burden on diabetic patients Tokai University, etc.

University Journal Online Editorial Department

　Research groups at Tokai University, Tohoku University, and Osaka University have succeeded in chemically synthesizing a novel artificial insulin "selenoinsulin" in which one of the disulfide bonds contained in natural insulin is replaced with a diselenide bond.As a result, it is expected to be applied as a novel insulin preparation that has a long-lasting medicinal effect in the body in the treatment of diabetes.

　While insulin preparations are the only life-threatening drug for diabetics, frequent subcutaneous administration is physically and mentally burdensome.In the field of drug discovery, the development of a new long-acting insulin preparation that circulates and acts in the body for a long time to support the basal secretion of insulin has been an issue in order to reduce the burden on patients.

　After administration, insulin circulates in the body through the bloodstream and is finally decomposed by insulin-degrading enzyme (IDE) in the kidney and excreted as urine.If insulin that shows high decomposition resistance to this IDE (= long time to decompose) can be artificially created, it will lead to the development of a new type of long-acting insulin preparation that circulates in the body for a long time. Was done.

　The research group focused on the reactivity of selenium atoms and the stability of diselenide bonds.Succeeded in the chemical synthesis of a novel artificial insulin "selenoinsulin" in which one of the disulfide bonds contained in natural insulin (derived from bovine pancreas) is replaced with a diselenide bond. It turned out to be equivalent to insulin.Furthermore, it was found to show remarkable degradation resistance to insulin-degrading enzyme (IDE) present in the body.

From the results of this study, it is considered that "selenoinsulin" has a long-lasting medicinal effect in the body, and its application as a new long-acting insulin preparation is expected.

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Tokai University

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