Jet lag occurs when the rhythm of the body clock is disturbed when the rhythm of day and night changes due to the time difference.Each cell in the body has a biological clock, but it is the clock cell population in the brain that bundles them.Each clock cell repeats gene expression in a cycle of about 24 hours, and the biological clock functions in rhythm.The research group expressed the behavior of this rhythm group with a mathematical formula, and predicted the rhythm when a time difference was given.

　As a result, in the time difference where the local time was delayed (one day became longer), the rhythm of the clock cells remained well aligned in the group, and it was possible to adjust to the day and night rhythm in a few days.On the other hand, when the local time was earlier (one day was shorter), the rhythm of the group became disjointed, and it was difficult to match the timing with the rhythm of day and night, and the recovery from jet lag was prolonged.

　From these results, the research group thought that jet lag was a major cause of jet lag, and simulated the case where jet lag was given in small portions.As a result, it was confirmed that the rhythm did not fall apart and the recovery from the time difference was accelerated by several days, and its effectiveness could be demonstrated by experiments using mice.
In other words, it is explained that if the local time is early when traveling to the east, getting up early the day before and shortening the time difference received will facilitate adaptation.

　It is also expected that the method used this time can be applied to schedule making that reduces the burden on shift workers.

Paper information:[Scientific Reports] Accelerating recovery from jet lag: prediction from a multi-oscillator model and its experimental confirmation in model animals