Associate Professor Shinobu Yasoo of the Graduate School of Agriculture, Kyushu University and Professor Shigekazu Higuchi of the Graduate School of Arts and Engineering have collaborated with FANCL Co., Ltd. to correct the body clock when L-serine, a type of amino acid, is ingested. Clarified that it will be easier.
The human body is equipped with a biological clock that controls physiological activities such as sleep, arousal, hormone secretion and blood pressure to match the day and night rhythm.Since the human body clock is originally longer than 24 hours, the hands are adjusted every day by being exposed to the morning light, but if the daily rhythm is frequently disturbed, the hands cannot keep up.If the body clock is disturbed, the risk of lifestyle-related diseases such as diabetes and cancer may increase.
This time, the research group discovered through mouse experiments that ingestion of L-serine, which is one of the amino acids, enhances the hand alignment of the biological clock by light.Furthermore, when the day-night rhythm was shifted by 6 hours to induce artificial jet lag and then serine was ingested at a fixed time, the hands of the body clock advanced faster and tuned to the new rhythm quickly.
Even in the case of male university students as subjects, by ingesting serine and irradiating with light in the morning, the start time of melatonin secretion, which indicates the hands of the body clock, is greatly advanced, and similar results can be obtained in human tests. Demonstrated.It is expected that this result will be able to nutritionally improve the disorder of the body clock and jet lag, and can be applied to a wide range of applications such as health management of shift workers.
Paper information:[Journal of Nutrition] L-Serine Enhances Light-Induced Circadian Phase Resetting in Mice and Humans
