Research by Nagoya City University and Chubu University has revealed that raising the temperature of the environment in which Alzheimer's disease model mice are reared raises core body temperature, which in turn promotes cognitive dysfunction and pathology related to Alzheimer's disease. became.

 Alzheimer's disease has been shown to cause impaired or decreased thermoregulatory function, but the causal relationship between body temperature and the progression of Alzheimer's disease has not been clarified.Therefore, the present group found that the rearing environment temperature of Alzheimer's disease model mice was increased (23°C → XNUMX°C). It was found that the phosphorylation of tau protein was highly enhanced due to the increase in tau protein levels.

 With global warming, temperatures are rising on a global scale, and it has become clear that the progression of Alzheimer's disease is strongly influenced by body temperature. has an important meaning.

Paper information:[Scientific Reports] Sustained high body temperature exacerbates cognitive function and Alzheimer's disease-related pathologies

Nagoya City University

Fostering excellent human resources who will lead the next generation, energetically challenging international and interdisciplinary research

Opened as a public university consisting of medical and pharmaceutical schools, it is now an urban university consisting of 7 faculties and 7 graduate schools. In 2016, the Graduate School of Economics "Medical Economics Management Course", the Graduate School of Medicine "Clinical Medical Design", and the Graduate School of Human Culture "Clinical Psychology Course" were established, opening up new academic fields. …]

Chubu University
Chubu University

A comprehensive university where 8 faculties and 27 departments gather on one campus to cultivate true abilities that can be used in the real world.

About 1 people study on one campus.Facilities that respond to curiosity, laboratories that receive research requests from society, and professors who are highly evaluated in each field stimulate your creativity. It is a university where you can do what you want to do and become the person you want to be. […]

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