Dentist Mitsuru Tamura (graduate student of dentistry) of Niigata University and Associate Professor Tomoki Maekawa, Professor Yutaka Terao and others have clarified that the components extracted from rice can suppress alveolar bone resorption at the onset of periodontal disease.
Periodontal disease is one of the national diseases that begins to occur in the early adulthood and affects many middle-aged and elderly people in Japan.Initially, inflammation of the gingiva is the main sign, but it becomes more severe over time and resorbs the alveolar bone around the teeth.In current dental practice, recovery of resorbed alveolar bone is extremely difficult and can lead to tooth loss.Prevention of periodontal disease, that is, protection of alveolar bone, is important for national health, because if you do not chew food with your own teeth, it will have various adverse effects on general health.
It was suggested that the rice component has an anti-inflammatory effect.Therefore, the research group made 15 kinds of peptide solutions extracted from rice act on model mice with periodontal disease, and analyzed the effect of suppressing alveolar bone resorption with a CT device or the like.As a result, we succeeded in finding a rice peptide that has an alveolar bone resorption inhibitory effect from 15 types of rice peptide solutions.In addition, when the mechanism of suppressing alveolar bone resorption was analyzed at the genetic level, it was also found that the rice peptide suppresses biomolecules that induce bone resorption and gingival inflammation.
Antibiotics used to control periodontal disease-causing bacteria have the risk of producing "drug-resistant bacteria" when abused.Therefore, the Japanese government has established an "AMR (drug resistance) action plan" that includes the reduction of antibiotic use.Since rice is a food that is consumed on a daily basis and is safe for humans, this study has the potential to expand into new treatments and preventions for periodontal disease that also lead to restrictions on the use of antibiotics.In the future, he is considering developing industry-academia collaborative research with US-related companies based in Niigata.
Paper information:[Archives of Oral Biology] Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis
