Top > Research results > What is the intestinal environment that is prone to colorectal cancer? Osaka University and others identify related bacteria in the early stages of colorectal cancer

2019/6/13

What is the intestinal environment that is prone to colorectal cancer? Osaka University and others identify related bacteria in the early stages of colorectal cancer

University Journal Online Editorial Department

　Research groups such as Osaka University, Tokyo Institute of Technology, Tokyo University, and Keio University conducted metagenome analysis and metabolome analysis using stools on 616 patients who underwent colonoscopy (colonoscope). We have succeeded in identifying bacteria and metabolites characteristic of the stool of patients with multiple polyps (adenomas) and intramucosal cancer, which are precancerous lesions.

　Colorectal cancer, which has overtaken gastric cancer and has become the most common cancer in Japan, progresses to advanced cancer via colorectal polyps (adenomas) and intramucosal cancer.So far, some bacteria characteristic of advanced colorectal cancer have been identified, but for colorectal polyps (adenomas) and intramucosal cancer, which are the stages before advanced cancer, related bacteria and metabolites have been identified. Was not known.

　This time, the research group investigated the characteristics of the intestinal environment at each stage of cancer by making full use of metagenomic analysis (decoding of DNA genome sequence) and metabolome analysis (component analysis of metabolites).Then, it was found that even with the same colorectal cancer, the intestinal bacteria and intestinal metabolites that increase or decrease in the stool differ greatly depending on the stage of cancer progression.For example, Atopobium parvulum and Actinomyces odontolyticus have been identified as bacteria that are elevated only in the stage of multiple polyps (adenomas) and intramucosal cancers. It was strongly suggested that bacteria are associated with the early onset of colorectal cancer.

　This finding, which clarified the intestinal environment related to colorectal cancer carcinogenesis, is expected to lead to early diagnosis and prevention of colorectal cancer, and application to "preemptive medicine" that treats colorectal cancer before it develops. NS.

Paper information:[Nature Medicine] Metagenomic and metabolomic analyzes reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer

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The University of Tokyo was established in 1877 (Meiji 10) by integrating the Tokyo Kaisei School and the Tokyo Medical School.Since its establishment, it has developed education and research in a unique way in the world as a leading university in Japan and an academic center for the fusion of East and West cultures.As a result, many human resources have been produced in a wide range of fields, and many research achievements […]

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Osaka University

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Osaka University is a research-based university with 11 faculties and 23 departments. Since its founding in 1931, with the motto of "living in the region and extending to the world," we have created an outstanding "foundation" and "power" that weaves advanced education and research capabilities, the harmony of faculty and staff, and the weight of tradition and the advantage of Osaka. I have.Taking advantage of these excellent potentials […]

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Tokyo Institute of Technology

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Tokyo Institute of Technology was established as the Tokyo Institute of Technology in 1881 (Meiji 14), when modernization of industry was an urgent need.Since its establishment, it has continued to produce excellent research results with excellent science and engineering human resources, and is still at the top of Japan's science and engineering universities.Tokyo Institute of Technology requires not only a high degree of specialization but also liberal arts […]

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Keio University

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