Aortic dissection is a disease with a poor prognosis in which the media of the aortic wall suddenly breaks, and surgery after the onset is currently the only treatment method.Although it is desired to predict the onset and develop medical treatment / prevention methods, the mechanism of onset has not been elucidated because there is no animal model suitable for aortic dissection.

　Epidemiologically, the olive oil-rich Mediterranean diet is said to help prevent arterial disease.Fatty acids such as oleic acid contained in olive oil and linoleic acid contained in corn oil are taken up by phospholipids constituting cell membranes and then released by the action of PLA2 when necessary.

　In this study, we found that sPLA2-V, a type of PLA2, is highly expressed in vascular endothelial cells of mouse aorta.Therefore, we found that when angiotensin II, a blood pressure-increasing substance, which is considered to be one of the main causes of aortic dissection, was administered to mice lacking sPLA2-V, aortic dissection frequently developed.
In the aorta of sPLA2-V-deficient mice, the induction of lysyl oxidase (LOX), which promotes cross-linking of the cellular matrix, was reduced, and the release of oleic acid and linoleic acid was reduced.On the other hand, oleic acid and linoleic acid were found to enhance LOX expression, and feeding sPLA2-V-deficient mice a high oleic acid diet or a high linoleic acid diet suppressed the onset of aortic dissection.

　These results suggest that sPLA2-V has a role in stabilizing the arterial wall and preventing aortic dissection by promoting LOX production through the release of oleic acid and linoleic acid and enhancing cross-linking of the cell matrix. rice field.

　This result is expected to lead to the development of new preventive and therapeutic methods for aortic dissection.

Paper information:[Journal of Biological Chemistry] Group V secreted phospholipase A2 plays a protective role against aortic dissection