When a person eats, insulin is secreted from the pancreas, and sugar is absorbed by skeletal muscle, fat, and liver to lower the blood sugar level.Insulin resistance refers to a state (resistance) in which insulin is less effective against these tissues.

　In recent years, it has become clear that insulin resistance occurs when fat accumulates in the liver and skeletal muscle even in non-obese people, and that Asians are more likely to develop fatty liver even if they are thin, but it was unknown for Japanese people.This time, 70 Japanese non-obese people were investigated for the relationship between insulin resistance, metabolic disorders, and ectopic fat accumulation (fatty liver and fat muscle).

　As a result, when non-obese persons (BMI [body mass index] 23-25) have at least one cardiovascular metabolic risk factor (hyperglycemia, dyslipidemia, hypertension), insulin resistance in skeletal muscle becomes obese. (BMI 1 to 25 combined with metabolic syndrome) was recognized in the same manner.In addition, factors related to insulin resistance in skeletal muscle included low physical fitness, low activity, visceral fat accumulation, and a high-fat diet.Furthermore, even mild liver dysfunction and hepatic fat accumulation have been shown to be associated with skeletal muscle insulin resistance, which may be a marker of muscle insulin resistance.

　From this survey, it is recommended that non-obese people who are at risk of cardiometabolic metabolism should pay attention to lifestyle habits in addition to weight loss, increase their daily activity (walking, etc.) and improve their physical fitness (jogging, etc.). That is.In the future, it is necessary to verify the unclear points of the causal relationship, but it is expected to be used in preventive medicine.