A study by the University of Tokyo and the National Center for Child Health and Development found that atopic dermatitis had an increased concentration of urinary lipids, suggesting that it may be useful as a new urinary biomarker for atopic dermatitis. Was done.
In the diagnosis of atopic dermatitis, biomarker measurement in blood is mainly used by blood sampling, but since this disease often develops in infancy, development of a method that does not burden small children with blood sampling. Is required.Therefore, this group decided to search for biomarkers of atopic dermatitis in urine, which is easy to collect even from children, and analyzed the urinary substances of atopic dermatitis model mice.
As a result, in the urine of mice with atopic dermatitis, the lipid metabolites 13,14-dihydro-15-keto-tetranor-PGF1α and 13,14-dihydro-15-keto-tetranor-PGE2, 13,14- The concentration of dihydro-15-keto PGJ2 was increased.In addition, when the expression of inflamed skin genes and proteins was confirmed, an increase in the expression of enzymes involved in the synthesis of these lipids was observed.In other words, it is considered that inflamed skin epithelial cells (keratinocytes) are the producers of these lipids, and their metabolites are excreted in urine.
Based on this result, the urinary lipids of patients with atopic dermatitis who visited the National Center for Child Health and Development were also measured, and it was confirmed that the above lipids were also excreted in large quantities.Similar to mice with atopic dermatitis, it is considered that lipids produced in the skin are metabolized and lipid metabolites are excreted in urine in patients with atopic dermatitis.
This result is expected to be useful for the development of a new urinary biomarker capable of diagnosing atopic dermatitis without the need for blood sampling.
Paper information:[The FASEB Journal] Urinary lipid profile of atopic dermatitis in murine model and human patients
