A joint research group of Aichi Medical University, Nagoya University, and Kurume University confirmed that the new food material pyrroloquinoline quinone (PQQ) extends the adult lifespan of the nematode C. elegans by more than 30%, and the life extension mechanism of PQQ. Was revealed for the first time in the world.
The group found that giving adult nematodes, which are often used as model animals when studying aging and longevity, to PQQ, which has been commercialized as a new food material, increases lifespan by more than 30%.Furthermore, PQQ acts on the cell membrane-specific reactive oxygen species synthesis / degradation system to generate low levels of reactive oxygen species ROS on the cell membrane, and this low level of ROS is the intracellular defense response. We have discovered a "life extension mechanism" that achieves longevity by functioning important gene groups and strengthening biological defense.
Previously, reactive oxygen ROS were thought to be an aging-promoting factor that damages biopolymers, but in recent years, "low-level ROS" produced by mitochondria have been rather prolonging lifespan. It is reported that "low level ROS" is the mainstream idea that it is beneficial for life.The result of this research is the discovery of longevity by low-level ROS derived from cell membranes, not mitochondria, for the first time in the world, and the "mechanism of producing low-level ROS that induces longevity" that was completely unknown until now. It is significant in that it succeeded in elucidating it ahead of time.
Journal of Cell Science] Life span extension by peroxidase / dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in C. elegans
