Professor Takashi Yokoo of the Jikei University School of Medicine succeeded in urinating from a regenerated kidney transplanted in collaboration with Keio University, Meiji University, and Kitasato University.In the future, if it becomes possible to continuously develop regenerative kidneys, the clinical application of regenerative medicine for kidneys will greatly advance.
Therefore, Professor Yokoo and his colleagues thought that continuous growth would be possible if the urinary tract could be constructed.First, the pre-growth kidney with a bladder transplanted to the rat is developed.By connecting the ureter that the rat originally had to the bladder by a surgical method, it was confirmed that urine was excreted normally.We also showed that the same method can be applied to cloned pigs.
In the future, we aim to build a urinary excretion route in the regenerated kidney with primate marmosets that are closer to humans.In addition, since we have not succeeded in making all the ureters and urinary bladder of new kidneys from human-derived cells, we are also working on the development of a method for suppressing rejection after transplantation.Further research in the future will enable patients with renal failure to regain a healthy life.