A research group from NOSAI Hokkaido, Okayama University, Hokkaido University, and Azabu University has clarified that the intrauterine microflora of cattle forms different microbiota due to differences in feeding management for each farm, and that it changes in relation to fertility. bottom.

 Cows that do not conceive even after three or more artificial inseminations (repeat breeders) have no abnormalities in their ovaries and uterus and have a normal estrous cycle. inflicting economic losses on dairy farmers.The ratio of repeat breeders is 3 to 1%, and countermeasures are required.

 In recent years, advances in analysis technology have revealed the presence of intrauterine microflora in the uterus, which has been considered sterile, and is attracting attention as a new cause of subfertility.This time, the research group examined the usefulness of bovine intrauterine microbiota testing.

 We analyzed the intrauterine microbiota of 4 cattle from four farms with different feeding management, and examined differences in intrauterine microbiota with respect to farms, feeds fed, and rearing methods. It was found to affect the microbiota.

 Furthermore, when we analyzed the relationship between intrauterine microflora and low fertility in 1 cows from one farm, we found that a specific bacterium (Arcobacter) was associated with low fertility.In addition, we conducted an analysis (co-occurrence network analysis) to find out the cooperation system between bacteria, and found positive and negative relationships between bacteria related to low fertility.This enabled the detection of bacterial groups associated with low fertility.

 As research progresses, uterine microbiome testing (a test to determine whether the microbial environment in the uterus is optimal for embryo implantation) has been established as a new approach to diagnose the cause of low fertility. It is expected to contribute to the improvement of breeding management.

Paper information:[Microbiology Spectrum] Metataxonomic Analysis of the Uterine Microbiota Associated with Low Fertility in Dairy Cows Using Endometrial Tissues Prior to First Artificial Insemination

Hokkaido University

Strong cooperation with industry and regions "Practical science unique to Hokkaido University" leads the world

The origin of Hokkaido University dates back to Sapporo Agricultural College, which was established in 1876.Throughout its long history, we have cultivated the basic principles of "frontier spirit," "cultivating internationality," "education for all," and "emphasis on practical studies."Based on this philosophy, he has a high level of academic background that is internationally accepted, and has accurate judgment and a leader […].

Azabu University

Aim to become a specialist by learning closely about our lives such as animals, food, environment and health!

The roots of Azabu University go back to the "Tokyo Veterinary Training Center" established in 23 by Totaka Yokura in Azabu, Tokyo (currently Minami Azabu, Minato-ku). Opened as Azabu Veterinary University in 1890 and renamed Azabu University in 1950.At Azabu University, under the founding spirit of "the study of science and sincere practice" […]

Okayama University

Promote the creation of an environment and system that can fly as a practitioner who can play an active role globally

A national university with 150 faculties, 10 graduate schools, and 8 research institutes, which is about 4 years old.Based on the results of advanced research activities, we can cultivate the ability of students to participate in "creation of knowledge" independently, and foster a rich humanity through close dialogues and discussions between students and faculty members. In a wide range of fields both domestically and internationally […]

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