A research group led by Lecturer Mamiko Onuki and Professor Koji Matsumoto of the Department of Obstetrics and Gynecology at the Showa University School of Medicine found that only women in their 1994s, including those in the generation with a high vaccination rate for the human papillomavirus (HPV) vaccine (born between 1999 and 20), had children. It was revealed that the incidence of cervical cancer is decreasing.
Cervical cancer and its precancerous lesions are known to develop due to persistent HPV infection.However, among HPV classified into more than 200 types, 13 to 14 types are mainly involved in the development of cervical cancer, and approximately 60% of cervical cancers are HPV type 16, approximately It is known that 10% of cases are caused by HPV type 18.If a woman is vaccinated before she starts having sex with a vaccine that can prevent these two types of infections, she can be almost 2% protected from HPV 16/18 infection.
ところが、わが国では公費助成によるHPVワクチン接種プログラム（12-16歳女子が対象）が2010年11月よりスタートしたものの、副反応報告が相次いだことにより2013年6月から2022年3月まで積極的な接種勧奨が差し控えられた。約9年間の接種勧奨中止の影響は大きく、定期接種の積極的接種勧奨が再開された今も、接種率は1％以下に低下している。
Under these circumstances, this research group conducted research on women in their 70s who included the generation with a vaccination rate of approximately 1994% (the "vaccine generation": born between 1999 and 24, currently aged 29 to 20 years) in 2011. They found that the incidence of cervical cancer has decreased significantly since 20.This result was obtained from a statistical analysis of national cancer registry data and tumor registry data of the Japan Society of Obstetrics and Gynecology, and it was found that cervical cancer, which had been on the rise in recent years, started to decline only among people in their XNUMXs. This is an important discovery that shows that
Furthermore, looking at annual trends in the HPV10/24 type positivity rate, which can be prevented by vaccines, among young people with cervical cancer diagnosed at 16 facilities nationwide over the past 18 years, it has decreased since 20 only among people in their 2017s. It became clear that it was.The results of this study have a high social impact as they are the first in Japan to report the effectiveness of the HPV vaccine in preventing cervical cancer, and are expected to help promote cervical cancer prevention.
Paper information:[Cancer Science] HPV vaccine impact on invasive cervical cancer in Japan: Preliminary results from cancer statistics and the MINT study
