In collaboration with Professor Shingo Iwami of Kyushu University, Professor Yoshio Koyanagi of Kyoto University, and Professor Kazuyuki Aihara of the University of Tokyo, we have developed a method for quantifying the mode of HIV transmission.It may lead to a radical cure for AIDS that has not yet been cured.

 Human immunodeficiency virus type I (HIV-1) causes AIDS by infecting immune cells.It is known that there are two ways in which a virus can spread in the body.One is cell-free, which is a method in which a virus is released from an infected cell and the virus attaches to other cells.The other is cell-to-cell, which is a method in which cells come into direct contact with each other and pass the virus to spread the infection.It was thought that the former contributed mainly to the progress of AIDS, but in 2 it was reported that cell-to-cell infection may not be the cause of the cure of AIDS. It is attracting attention.

 The research group aimed to quantify the contribution of cell-free and cell-to-cell to the spread of HIV-1 infection.A notable technique is to create an environment where cell-to-cell infection does not occur by culturing cells while shaking the flask.By mathematically analyzing the data obtained in this way and the data obtained from normal culture, we succeeded in quantifying the contribution of cell-free and cell-to-cell.According to this, cell-to-cell infection accounts for 60% of cell-to-cell infections, accelerating the rate of spread of infection in the body by 3.9 times.It shows the importance of cell-to-cell infection in future AIDS research.

 Previous drug treatments may not have been able to control cell-to-cell infections, which may force a shift in treatment strategy.The research group will continue to aim to elucidate the whole picture of cell-to-cell infection.It can be expected to lead to the development of new drugs aimed at eradicating AIDS.

Tokyo University

Established in the 10th year of the Meiji era.A university with the longest history in Japan and at the forefront of Japanese knowledge

The University of Tokyo was established in 1877 (Meiji 10) by integrating the Tokyo Kaisei School and the Tokyo Medical School.Since its establishment, it has developed education and research in a unique way in the world as a leading university in Japan and an academic center for the fusion of East and West cultures.As a result, many human resources have been produced in a wide range of fields, and many research achievements […]

Kyoto University

Foster a free academic style based on the spirit of "self-respect for self-weight" and open up a world of creative learning.

With the motto of self-study, we will continue to maintain a free academic style that is not bound by common sense, and develop human resources who have both creativity and practical ability.We provide an inclusive learning space that allows for diverse and hierarchical choices so that students themselves can choose a solid future through valuable trial and error. […]

Kyushu University

A university that creates "comprehensive knowledge" that opens up the future and drives social change

Kyushu University, which celebrated its 111th anniversary this year, is a core university with 12 faculties and 19 faculties.We have been designated as a "designated national university corporation" that can be an international base by developing the world's highest level of outstanding education and research activities.From the humanities and sociology that we have cultivated so far to the natural sciences, and even the design-related "knowledge" […]

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