A research group led by Shintaro Sato, a specially appointed associate professor at Osaka University (also serving as an associate professor at Osaka City University Graduate School), confirmed that acidic or alkaline disinfectant alcohol has the effect of almost completely inactivating human norovirus. ..This alcohol solution can be adjusted only with food additives such as citric acid and baking soda, and can be expected to disinfect and decontaminate fingers, clothes, and metals in place of sodium hypochlorite, which has a strong bleaching and corrosive effect. ..
Human norovirus is an infectious disease virus that infects only humans and causes diarrhea and vomiting.Little progress has been made in research because it could not be increased outside the human body.Until now, due to the characteristics of human norovirus, it has been considered that it is not inactivated by surfactants, inverted soaps, and rubbing alcohol.Although some products have the impression that acidic alcohol preparations are effective, the actual effect was unknown.
The research group has previously developed a human norovirus proliferation system using intestinal epithelial cells prepared from human iPS cell lines and demonstrated that it can be inactivated by heating or sodium hypochlorite.This time, using the same method, a solution containing about 3 million human norovirus particles was treated with 9 to 30 times the volume of acidic or alkaline alcohol for 4 seconds.As a result, human norovirus almost completely lost its ability to infect and propagate.In addition, the most epidemic virus (GII.XNUMX) was almost completely inactivated by treatment with neutral alcohol.
However, when considering commercially available alcohol preparations, some of them were ineffective.Product additives appear to be an inhibitory factor.Currently, there is no method or standard for quantifying inactivation of human norovirus, not limited to alcohol preparations.Based on the results of this research, it is expected that inactivation methods using the proliferative capacity of human norovirus as an index will be standardized, and that disinfection and decontamination agents will be tested.
Paper information:[Scientific Reports] Alcohol abrogates human norovirus infectivity in a pH-dependent manner
