The research group of Associate Professor Ryuichi Tatsumi, Assistant Professor Ko Mizunotani, and Associate Professor Mako Nakamura of the Graduate School of Agriculture, Kyushu University discovered for the first time in the world the mechanism by which anti-fatigue muscle fibers are formed in muscles.
The characteristics of muscles are determined by the type of muscle cells called "muscle fibers".There are two types of muscle fibers, anti-fatigue (common in marathon athletes) and easy fatigue, but the mechanism by which the type is determined during muscle growth and regeneration has not been known so far.
Associate Professor Tatsumi and his group found that inactivating the semaphorin 3A (Sema3A) gene in muscle stem cells (satellite cells) almost completely eliminates anti-fatigue muscle fibers.We also elucidated a series of intracellular signal transduction mechanisms starting with the binding of Sema3A to the cell membrane receptor.
In this study, the formation of muscle fibers that are less likely to fatigue begins with the binding of Sema3A to cell membrane receptors, but the research group also found that certain food ingredients bind to Sema3A receptors. We have discovered that it is a factor that generates signals.Taking this food ingredient as a supplement may increase anti-fatigue muscle fibers.In the future, it is expected that ingestion of these supplements will increase anti-fatigue muscle fibers and suppress the decrease in endurance associated with aging and bedridden.
Paper information:[STEM CELLS] Slow-Myofiber Commitment by Semaphorin 3A Secreted from Myogenic Stem Cells
