A joint research group consisting of 19 institutions nationwide*, including the National Cancer Center, found that individual differences in genes that determine susceptibility to lung adenocarcinoma are more likely to occur in non-smokers, and lung adenocarcinomas with mutations in the EGFR gene are more likely to develop in non-smokers. It was revealed that it is strongly related to the susceptibility to cancer.

 Lung adenocarcinoma, which occurs most frequently among lung cancers, has a relatively weak relationship with smoking, which is a risk factor for lung cancer, and about half of cases occur in non-smokers.Risk factors other than smoking have not been identified, making it difficult to identify risk groups and prevent the onset of the disease.In particular, in Asian countries including Japan, many cases of lung adenocarcinoma occur due to mutations in the gene called EGFR (epidermal growth factor receptor).

 The joint research group compared genetic polymorphisms in approximately 1 Japanese patients with lung adenocarcinoma and approximately 7 patients without lung cancer, and determined which genes are preferentially carried by patients with lung adenocarcinoma. We identified individual differences inWe performed whole-genome sequence analysis of peripheral blood DNA from 15 patients with lung adenocarcinoma and investigated the relationship between individual genetic differences and telomere sequence length.

 As a result, 19 individual differences in the genes that determine the susceptibility to lung adenocarcinoma in Japanese people were identified, and some of these are related to lung adenocarcinoma with mutations in the EGFR gene, which often occurs in non-smokers. It was found that there is a strong relationship with susceptibility.

 In addition, individual differences in some genes have been shown to increase susceptibility to lung adenocarcinoma by elongating telomere sequences, which exist at the ends of chromosomal DNA and are involved in genome stabilization.It is known that the length of telomeres at the ends of chromosomes is related to cell lifespan and genome stability.

 The results of this study are expected to provide clues for the prevention and early detection of lung adenocarcinoma in non-smokers.

*In addition, Aichi Cancer Center, RIKEN, University of Tokyo, Shiga University of Medicine, Tokyo Medical and Dental University, Japanese Red Cross Medical Center, Kanagawa Cancer Center, Akita University, Saga University, Nagoya University, Shinshu University, Participating companies include Fukushima Medical University, Gunma University, Kyoto University, Tohoku University, Iwate Medical University, Okayama University, and Stargen Co., Ltd.

Paper information:[Journal of Clinical Investigation]FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters

Tokyo University

Established in the 10th year of the Meiji era.A university with the longest history in Japan and at the forefront of Japanese knowledge

The University of Tokyo was established in 1877 (Meiji 10) by integrating the Tokyo Kaisei School and the Tokyo Medical School.Since its establishment, it has developed education and research in a unique way in the world as a leading university in Japan and an academic center for the fusion of East and West cultures.As a result, many human resources have been produced in a wide range of fields, and many research achievements […]

Fukushima Medical University
Nagoya University

Aiming to be a person who has true courage and intellect and can open up the future

Nagoya University is a comprehensive university with 9 faculties, 13 graduate schools, 3 affiliated research institutes, nationwide joint usage, and 5 joint research centers.Through creative research activities, he explores the truth and produces some of the best intellectual achievements in the world.Foster courageous intellectuals with abundant logical thinking and imagination through educational practices that emphasize spontaneity […]

Kyoto University

Foster a free academic style based on the spirit of "self-respect for self-weight" and open up a world of creative learning.

With the motto of self-study, we will continue to maintain a free academic style that is not bound by common sense, and develop human resources who have both creativity and practical ability.We provide an inclusive learning space that allows for diverse and hierarchical choices so that students themselves can choose a solid future through valuable trial and error. […]

Tokyo Medical and Dental University

Fostering excellent global medical personnel with rich humanity based on the history and achievements of close cooperation between medicine and dentistry

As Japan's only comprehensive medical graduate university, in the fields of medicine and dentistry, human resources who can play an active role on the world stage, a wide range of education and rich humanity, high ethical standards, creativity and pioneering ability to think and solve by oneself, internationality Foster human resources with leadership skills.Excellent faculty, excellent facilities, and a world-class curriculum […]

Gunma University

Pursuing the academic discipline that you have decided on your own, "Run through the group, run the world"

Gunma University was established as a new national university in 24, and has four faculties representing the northern Kanto region (4 majors in the Faculty of Joint Education, Department of Social Informatics in the Faculty of Social Informatics, 13 majors in the Department of Health Sciences, Faculty of Medicine, and 4 in the Faculty of Science and Technology). It is a comprehensive university of the department).A wide range of international […] who can tackle new difficult issues enthusiastically and creatively.

Tohoku University

Create excellent research results that will be the source of innovation, and develop talented human resources who will lead the next generation

Tohoku University has a rich culture and humanity based on the tradition of "research first principle" since its opening, the idea of ​​"opening the door" and the spirit of "respect for practical science", and is a phenomenon of human beings, society and nature. In response to this, human resources with the ability to carry out intellectual exploration with a "scientific mind", demonstrating their expertise in various fields from an international perspective and leading […]

Shiga Medical University

"A university that is supported by the community, contributes to the community, and challenges the world"

We will develop trusted medical personnel through education and research in unique medicine and nursing while making the best use of the characteristics of the region.Furthermore, by training researchers who disseminate information to the world, we will contribute to the improvement and development of human health, medical care, and welfare.While conferring a wealth of education and a high degree of specialized knowledge and skills, a solid […]

Shinshu University

Fostering human resources with abundant human and practical skills in local and global societies

Shinshu University is a wide-area campus-type general university with five campuses in Nagano Prefecture.It consists of eight faculties: humanities, pedagogy, economics, science, medicine, engineering, agriculture, and textiles, and conducts education and research to acquire a wide range of education and basic abilities.Utilizing common education across faculties and the regional characteristics of Shinshu, which is rich in nature […]

Iwate Medical University

Fostering sincere human beings through medical education, dentistry education, pharmacy education and nursing education

A unique medical university where students from the four faculties of medicine, dentistry, medicine, and nursing study on the same campus.While each faculty demonstrates a high degree of autonomy, we are learning the basis of patient-centered medical care and team medical care in an environment of education, research, and medical care that has no boundaries between faculties.In addition, with Harvard University in the United States regarding education and medical care […]

University Journal Online Editorial Department

This is the online editorial department of the university journal.
Articles are written by editorial staff who have a high level of knowledge and interest in universities and education.