The research group previously discovered that the biological clock, which controls the 24-hour rhythm of bioactivity, is associated with time-dependent changes in allergic symptoms.Allergic reactions occur primarily when immune cells react with allergens and release allergens.Since immune cells become sensitive to the resting period (at night in the case of humans) due to the biological clock, it is considered that the allergic reaction becomes stronger when allergic substances are encountered during the resting period.

　The body clock is affected by insomnia, stress, exercise, and meal times.The research group thought that irregular dietary timing might also affect allergies, and conducted experiments with mice.

　The mice were divided into three groups: a group that was fed freely for 24 hours, a group that was fed during the active period (at night in the case of nocturnal mice), and a group that was fed during the rest period (daytime), and the urticaria reaction was observed. ..As a result, a strong reaction was observed in the resting period group, and the rhythm of the body clock was also different from that in the normal state.From this, it was found that an irregular diet changes the rhythm of the body clock, and the appearance of allergic reactions differs from that of a regular diet.

　From this result, it was suggested that it is necessary to consider the timing of food intake in order to suppress allergic symptoms.It is possible to improve allergic symptoms simply by changing the meal time without increasing the amount of medicine.Currently, in collaboration with Kofu City and companies, he is planning a study to analyze the relationship between meal timing and allergic (hay fever, etc.) symptoms using a smartphone app.

Paper information:[Allergology International] Time-restricted feeding in rest phase alters IgE / mast cell-mediated allergic reaction in mice