A research group led by Professor Motoko Yanagida of Kyoto University has elucidated the mechanism by which acute kidney injury shifts to chronic kidney disease.Treatment of acute kidney injury has shown the potential to stop the transition to chronic kidney disease and end-stage kidney disease.
This time, Professor Yanagida's group proved that the damage to the proximal tubules seen in acute kidney injury spreads the pathological condition by changing the surrounding cells using a genetically modified animal that was originally created. ..Furthermore, it was revealed that the intensity and frequency of damage to the proximal tubule are factors in the transition to chronic kidney disease.
This result suggests that proper treatment of acute renal impairment and maintaining the health of the proximal tubule may prevent the transition to chronic kidney disease and end-stage renal disease.It is expected to lead to treatments that prevent or delay the introduction of dialysis.