The research team of Professor Tsuyoshi Sugiura of Kagoshima University Graduate School of Medical and Dental Sciences collected saliva and stool samples of colorectal cancer patients and healthy people in collaboration with Kagoshima University Hospital Gastroenterological Surgery and Osaka University Microbial Disease Research Institute. For the first time in the world, we found four types of oral bacteria that are commonly found in saliva and stool of patients with colorectal cancer.We believe that oral bacteria may be involved in the development of colorectal cancer.
According to Kagoshima University, the research team analyzed saliva and stool samples from about 50 patients with colorectal cancer and about 4 healthy people at the genetic level, and has been found in saliva and stool samples from patients with colorectal cancer. I found XNUMX kinds of bacteria that are indigenous to the oral cavity.Bacterial composition in the oral cavity and in the large intestine was different between patients with colorectal cancer and healthy people.
The research team believes that the bacteria are supplied from the oral cavity to the large intestine, suggesting that they may cause colorectal cancer. It is unknown whether the four bacteria were carried directly from the oral cavity to the large intestine or indirectly.
The research team is working on a method for diagnosing the development and risk of colorectal cancer by analyzing the bacteria contained in saliva.In addition, we will study methods to control intestinal bacteria and prevent colorectal cancer by methods such as dental treatment, oral care, and management of oral bacteria by diet.
It is said that about 700 species and 100 billion bacteria are resident in the oral cavity.While there are bad bacteria that cause tooth decay and periodontal disease, there are also good bacteria that are harmless.It has gradually become clear that when indigenous bacteria in the oral cavity reach another part of the body, they cause another disease.
Paper information:[Cancers] Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common—A Metagenomic Comparison with Healthy Subjects
