A research group at Nagoya University has revealed that 9-oxo-octadecadienoic acid (9-oxo-ODAs), a natural compound found in the calyx of eggplant, has an antitumor effect on cervical cancer cells. did.

 In Japan, eggplant stems have been used as a folk medicine for common warts, a disease associated with the human papillomavirus (HPV).In addition, this research group has previously reported that the ethanol extract of eggplant calyx suppresses genital warts, which is also an HPV-related disease, and has led to the identification of the active ingredient 9-oxo-ODAs.

 In this study, we investigated the effects of 9-oxo-ODAs on cervical cancer, which is caused by HPV infection, as well as common warts and genital warts.When 9-oxo-ODAs were administered to human cervical cancer cells to examine their effects, the expression of cyclin-dependent kinase 1 (CDK1), which is involved in cell division, was suppressed, and the expression of cyclin-dependent kinase 6 (CDK7), which is involved in the carcinogenesis of cervical cancer, was suppressed. The expression of E9 and EXNUMX proteins was also suppressed.As a result, it was found that administration of XNUMX-oxo-ODAs suppressed the proliferation of cervical cancer cells and also increased the number of apoptosis (cell death).

 Experiments using a mouse model also revealed that administration of 9-oxo-ODAs can suppress metastasis formation and proliferation of cervical cancer cells, confirming its antitumor effect on cervical cancer cells.

 Cervical cancer is one of the leading causes of cancer-related death among women worldwide.This study revealed that 9-oxo-ODAs exhibit antitumor effects by inhibiting the expression of CDK1 and HPV-derived proteins, inducing cell cycle arrest and apoptosis in cervical cancer cells. It is expected that oxo-ODAs can be a promising therapeutic agent for HPV-related diseases.In the future, we will investigate the mechanism of action of 9-oxo-ODAs in more detail, and aim to apply this to drug discovery and clinical treatment for cervical cancer and its precancerous lesion, cervical dysplasia. It is said that

Paper information:[Scientific Reports] 9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins

Nagoya University

Aiming to be a person who has true courage and intellect and can open up the future

Nagoya University is a comprehensive university with 9 faculties, 13 graduate schools, 3 affiliated research institutes, nationwide joint usage, and 5 joint research centers.Through creative research activities, he explores the truth and produces some of the best intellectual achievements in the world.Foster courageous intellectuals with abundant logical thinking and imagination through educational practices that emphasize spontaneity […]

University Journal Online Editor

This is the online editorial department of the university journal.
Articles are written by editorial staff who have a high level of knowledge and interest in universities and education.