A research group at Nagoya University has revealed that 9-oxo-octadecadienoic acid (9-oxo-ODAs), a natural compound found in the calyx of eggplant, has an antitumor effect on cervical cancer cells. did.
In Japan, eggplant stems have been used as a folk medicine for common warts, a disease associated with the human papillomavirus (HPV).In addition, this research group has previously reported that the ethanol extract of eggplant calyx suppresses genital warts, which is also an HPV-related disease, and has led to the identification of the active ingredient 9-oxo-ODAs.
In this study, we investigated the effects of 9-oxo-ODAs on cervical cancer, which is caused by HPV infection, as well as common warts and genital warts.When 9-oxo-ODAs were administered to human cervical cancer cells to examine their effects, the expression of cyclin-dependent kinase 1 (CDK1), which is involved in cell division, was suppressed, and the expression of cyclin-dependent kinase 6 (CDK7), which is involved in the carcinogenesis of cervical cancer, was suppressed. The expression of E9 and EXNUMX proteins was also suppressed.As a result, it was found that administration of XNUMX-oxo-ODAs suppressed the proliferation of cervical cancer cells and also increased the number of apoptosis (cell death).
Experiments using a mouse model also revealed that administration of 9-oxo-ODAs can suppress metastasis formation and proliferation of cervical cancer cells, confirming its antitumor effect on cervical cancer cells.
Cervical cancer is one of the leading causes of cancer-related death among women worldwide.This study revealed that 9-oxo-ODAs exhibit antitumor effects by inhibiting the expression of CDK1 and HPV-derived proteins, inducing cell cycle arrest and apoptosis in cervical cancer cells. It is expected that oxo-ODAs can be a promising therapeutic agent for HPV-related diseases.In the future, we will investigate the mechanism of action of 9-oxo-ODAs in more detail, and aim to apply this to drug discovery and clinical treatment for cervical cancer and its precancerous lesion, cervical dysplasia. It is said that
Paper information:[Scientific Reports] 9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins
